stream 0000213437 00000 n 0000257452 00000 n 0000225654 00000 n 0000326256 00000 n 0000202965 00000 n 0000210454 00000 n Hydrochloric acid and potassium chlorate give chloranil. Aniline combines directly with alkyl iodides to form secondary and tertiary amines; boiled with carbon disulphide it gives sulphocarbanilide (diphenyl thio-urea), CS(NHC 6 H 5) 2, which may be decomposed into phenyl mustard-oil, C 6 H 5 CNS, and triphenyl guanidine, C 6 H 5 N: C(NHC6H5)2. 0000316466 00000 n 0000215826 00000 n [33][34] The IARC lists it in Group 3 (not classifiable as to its carcinogenicity to humans) due to the limited and contradictory data available. endobj 0000224597 00000 n 0000222098 00000 n 0000285105 00000 n 0000301622 00000 n 0000275642 00000 n [7], Consistent with these factors, substituted anilines with electron donating groups are more pyramidalized, while those with electron withdrawing groups are more planar. 0000233877 00000 n 0000298293 00000 n Hypochlorous acid gives 4-aminophenol and para-amino diphenylamine. 0000229290 00000 n 0000310314 00000 n He named it kyanol or cyanol. Substance is dangerous for the environment. The first azo dye was aniline yellow. 0000275368 00000 n Hydrogenation gives cyclohexylamine. 0000208625 00000 n 0000214138 00000 n 0000253528 00000 n 0000193919 00000 n 0000239193 00000 n 0000274671 00000 n 0000328912 00000 n J Natl Cancer Inst. 0000287337 00000 n 0000218783 00000 n : 62-53-3 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Industrial & for professional use only. 0000124780 00000 n Aniline is an organic chemical compound, specifically a primary aromatic amine. Other aniline dyes followed, such as fuchsin, safranin, and induline. 0000319542 00000 n 0000291914 00000 n [6], In commerce, three brands of aniline are distinguished: aniline oil for blue, which is pure aniline; aniline oil for red, a mixture of equimolecular quantities of aniline and ortho- and para-toluidines; and aniline oil for safranine, which contains aniline and ortho-toluidine and is obtained from the distillate (échappés) of the fuchsine fusion. 0000198119 00000 n 0000308514 00000 n 0000038387 00000 n In aniline, the C−N bond length is 1.41 Å,[9] compared to 1.47 Å for cyclohexylamine,[10] indicating that there is partial π-bonding between N and C.[11], Industrial aniline production involves two steps. 0000254910 00000 n 0000297729 00000 n 0000302045 00000 n 0000289146 00000 n 0000256308 00000 n Cancer Res. 0000314810 00000 n 0000254080 00000 n 0000206710 00000 n 0000198452 00000 n 0000267373 00000 n 0000320826 00000 n 0000222267 00000 n 0000214279 00000 n Pharmacogenetics. 0000304591 00000 n 0000230463 00000 n 0000324870 00000 n 0000220093 00000 n Gerhard Domagk identified as an antibacterial a red azo dye, introduced in 1935 as the first antibacterial drug, prontosil, soon found at Pasteur Institute to be a prodrug degraded in vivo into sulfanilamide – a colorless intermediate for many, highly colorfast azo dyes – already with an expired patent, synthesized in 1908 in Vienna by the researcher Paul Gelmo for his doctoral research. 0000017887 00000 n 0000313291 00000 n 3 0 obj 0000246645 00000 n 0000242539 00000 n %%EOF 0000256445 00000 n Safety Information. : 142-04-1 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Industrial & for professional use only. 0000195434 00000 n 0000251700 00000 n 0000126848 00000 n 0000274397 00000 n 0000323911 00000 n 0000279949 00000 n 0000198620 00000 n 0000317049 00000 n [21][22] In 1842, Nikolay Nikolaevich Zinin reduced nitrobenzene and obtained a base that he named benzidam. 0000209711 00000 n 0000223706 00000 n 0000209429 00000 n 0000324322 00000 n 0000207515 00000 n Potassium permanganate in neutral solution oxidizes it to nitrobenzene; in alkaline solution to azobenzene, ammonia, and oxalic acid; in acid solution to aniline black. [29] Medications in high demand during World War II (1939–45), these first miracle drugs, chemotherapy of wide effectiveness, propelled the American pharmaceutics industry. trailer 0000295360 00000 n 0000244848 00000 n 0000214698 00000 n 0000038463 00000 n 0000217588 00000 n 0000196109 00000 n Like other amines, aniline is a base (pKaH = 4.6) and nucleophile, although it is a weaker base and poorer nucleophile than structurally similar aliphatic amines. ", http://www.nuclear-weapons.info/cde.htm#Corporal, CDC - NIOSH Pocket Guide to Chemical Hazrds, https://en.wikipedia.org/w/index.php?title=Aniline&oldid=989741451, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple CAS registry numbers, Chemical articles with multiple PubChem CIDs, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles with unsourced statements from May 2010, Wikipedia articles incorporating a citation from the 1911 Encyclopaedia Britannica with Wikisource reference, Wikipedia articles incorporating text from the 1911 Encyclopædia Britannica, Inconsistent wikidata for Commons category, Wikipedia articles incorporating a citation from EB9, Creative Commons Attribution-ShareAlike License, J. Fritzsche (1840) "Ueber das Anilin, ein neues Zersetzungsproduct des Indigo,", This page was last edited on 20 November 2020, at 19:36. 0000225214 00000 n 0000205574 00000 n 0000244989 00000 n Mlb The Show 20 Ratings Database, Gravity Rider Apk Mod, Best Japanese Tattoo Artist California, Oregon High School Baseball 2019, Pickled Seckel Pear Recipe, When Does School End In Singapore 2020, When Did Rear Seatbelts Become Mandatory In Uk, Captainsparklez Revenge Virtual Piano, List Of Legumes, Moto Metal Mo962 18x10, 2015 Ml350 Price, Lindera Benzoin Uses, List Of Legumes, Bristol Living Costs, Demonstrations In San Diego Today, The Presentation Of Self In Everyday Life Summary, Lg Un7300 43 Inch Specifications, Social Studies 10-1 Textbook Alberta Pdf, Hilti Distributors Uk, Social Studies 10-1 Textbook Alberta Pdf, Vermintide 2 2020 Unchained Build, Chain Restaurants In Front Royal, Va, " />

0000232531 00000 n 0000311563 00000 n 0000239784 00000 n 0000197117 00000 n 0000321249 00000 n [, Gan J, Skipper PL, Gago-Dominguez M, Arakawa K, Ross RK, Yu MC, Tannenbaum SR: Alkylaniline-hemoglobin adducts and risk of non-smoking-related bladder cancer. Its acetate is used in the aniline acetate test for carbohydrates, identifying pentoses by conversion to furfural. 0000300502 00000 n 0000325978 00000 n 0000326393 00000 n There are 27 proteins in total. 0000292744 00000 n 0000276472 00000 n 0000209263 00000 n (7) Conversion Factors: To convert concentrations in air (at 25°C) from ppm to mg/m 3: mg/m 3 = (ppm) × (molecular weight of the 0000199960 00000 n 0000239643 00000 n 0000201296 00000 n Aniline hydrochloride forms large colourless tables, which become greenish on exposure; it is the "aniline salt" of commerce. 0000241346 00000 n An idealized equation is shown: The resulting diamine is the precursor to 4,4'-MDI and related diisocyanates. 0000246234 00000 n 0000232359 00000 n 0000210043 00000 n 0000202126 00000 n 0000296057 00000 n 0000295187 00000 n 0000297314 00000 n 0000285383 00000 n Its main use is in the manufacture of precursors to polyurethane, dyes, and other industrial chemicals. Carcinogenesis. 0000219360 00000 n 0000273258 00000 n 0000321985 00000 n 0000197954 00000 n (1) Aniline has a characteristic odor and an odor threshold of 1.1 parts per million (ppm). Aniline is a slightly pyramidalized molecule, with hybridization of the nitrogen somewhere between sp3 and sp2. 0000194762 00000 n STABILITY AND REACTIVITY ... ANILINE HYDROCHLORIDE Marine pollutant: No IATA UN number: 1548 Class: 6.1 Packing group: III . 0000296476 00000 n 0000204136 00000 n 0000235075 00000 n 0000215685 00000 n 0000211316 00000 n 0000213997 00000 n 0000262342 00000 n 0000229796 00000 n [14]. [18] As additives to rubber, aniline derivatives such as phenylenediamines and diphenylamine, are antioxidants. 0000230796 00000 n 0000212462 00000 n 0000313710 00000 n 0000297870 00000 n 0000278837 00000 n 0000252694 00000 n Aniline combines directly with alkyl iodides to form secondary and tertiary amines. 0000329600 00000 n 0000317910 00000 n 0000324048 00000 n 2007, Wiley-VCH, Weinheim. 0000249774 00000 n 1 0 obj 0000241068 00000 n 0000260751 00000 n 0000238637 00000 n 0000301485 00000 n 0000226666 00000 n 0000226384 00000 n 0000254769 00000 n 0000264074 00000 n Crit Rev Toxicol. For example, reaction of aniline with sulfuric acid at 180 °C produces sulfanilic acid, H2NC6H4SO3H. The amino group in aniline is flatter (i.e., it is a "shallower pyramid") than that in an aliphatic amine, owing to conjugation of the lone pair with the aryl substituent. 0000249633 00000 n 0000303451 00000 n 0000237305 00000 n 0000225380 00000 n 0000249911 00000 n 0000325422 00000 n [23] In 1843, August Wilhelm von Hofmann showed that these were all the same substance, known thereafter as phenylamine or aniline. 0000253109 00000 n 0000278978 00000 n [, Kuo HM, Ho HJ, Chao PD, Chung JG: Quercetin glucuronides inhibited 2-aminofluorene acetylation in human acute myeloid HL-60 leukemia cells. 0000273677 00000 n 0000320967 00000 n The chemistry of aniline is rich because the compound has been cheaply available for many years. 0000315777 00000 n [32], Aniline is toxic by inhalation of the vapour, ingestion, or percutaneous absorption. 0000325285 00000 n 0000249222 00000 n 0000325563 00000 n 0000289561 00000 n 30 0 obj<>stream 0000213437 00000 n 0000257452 00000 n 0000225654 00000 n 0000326256 00000 n 0000202965 00000 n 0000210454 00000 n Hydrochloric acid and potassium chlorate give chloranil. Aniline combines directly with alkyl iodides to form secondary and tertiary amines; boiled with carbon disulphide it gives sulphocarbanilide (diphenyl thio-urea), CS(NHC 6 H 5) 2, which may be decomposed into phenyl mustard-oil, C 6 H 5 CNS, and triphenyl guanidine, C 6 H 5 N: C(NHC6H5)2. 0000316466 00000 n 0000215826 00000 n [33][34] The IARC lists it in Group 3 (not classifiable as to its carcinogenicity to humans) due to the limited and contradictory data available. endobj 0000224597 00000 n 0000222098 00000 n 0000285105 00000 n 0000301622 00000 n 0000275642 00000 n [7], Consistent with these factors, substituted anilines with electron donating groups are more pyramidalized, while those with electron withdrawing groups are more planar. 0000233877 00000 n 0000298293 00000 n Hypochlorous acid gives 4-aminophenol and para-amino diphenylamine. 0000229290 00000 n 0000310314 00000 n He named it kyanol or cyanol. Substance is dangerous for the environment. The first azo dye was aniline yellow. 0000275368 00000 n Hydrogenation gives cyclohexylamine. 0000208625 00000 n 0000214138 00000 n 0000253528 00000 n 0000193919 00000 n 0000239193 00000 n 0000274671 00000 n 0000328912 00000 n J Natl Cancer Inst. 0000287337 00000 n 0000218783 00000 n : 62-53-3 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Industrial & for professional use only. 0000124780 00000 n Aniline is an organic chemical compound, specifically a primary aromatic amine. Other aniline dyes followed, such as fuchsin, safranin, and induline. 0000319542 00000 n 0000291914 00000 n [6], In commerce, three brands of aniline are distinguished: aniline oil for blue, which is pure aniline; aniline oil for red, a mixture of equimolecular quantities of aniline and ortho- and para-toluidines; and aniline oil for safranine, which contains aniline and ortho-toluidine and is obtained from the distillate (échappés) of the fuchsine fusion. 0000198119 00000 n 0000308514 00000 n 0000038387 00000 n In aniline, the C−N bond length is 1.41 Å,[9] compared to 1.47 Å for cyclohexylamine,[10] indicating that there is partial π-bonding between N and C.[11], Industrial aniline production involves two steps. 0000254910 00000 n 0000297729 00000 n 0000302045 00000 n 0000289146 00000 n 0000256308 00000 n Cancer Res. 0000314810 00000 n 0000254080 00000 n 0000206710 00000 n 0000198452 00000 n 0000267373 00000 n 0000320826 00000 n 0000222267 00000 n 0000214279 00000 n Pharmacogenetics. 0000304591 00000 n 0000230463 00000 n 0000324870 00000 n 0000220093 00000 n Gerhard Domagk identified as an antibacterial a red azo dye, introduced in 1935 as the first antibacterial drug, prontosil, soon found at Pasteur Institute to be a prodrug degraded in vivo into sulfanilamide – a colorless intermediate for many, highly colorfast azo dyes – already with an expired patent, synthesized in 1908 in Vienna by the researcher Paul Gelmo for his doctoral research. 0000017887 00000 n 0000313291 00000 n 3 0 obj 0000246645 00000 n 0000242539 00000 n %%EOF 0000256445 00000 n Safety Information. : 142-04-1 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Industrial & for professional use only. 0000195434 00000 n 0000251700 00000 n 0000126848 00000 n 0000274397 00000 n 0000323911 00000 n 0000279949 00000 n 0000198620 00000 n 0000317049 00000 n [21][22] In 1842, Nikolay Nikolaevich Zinin reduced nitrobenzene and obtained a base that he named benzidam. 0000209711 00000 n 0000223706 00000 n 0000209429 00000 n 0000324322 00000 n 0000207515 00000 n Potassium permanganate in neutral solution oxidizes it to nitrobenzene; in alkaline solution to azobenzene, ammonia, and oxalic acid; in acid solution to aniline black. [29] Medications in high demand during World War II (1939–45), these first miracle drugs, chemotherapy of wide effectiveness, propelled the American pharmaceutics industry. trailer 0000295360 00000 n 0000244848 00000 n 0000214698 00000 n 0000038463 00000 n 0000217588 00000 n 0000196109 00000 n Like other amines, aniline is a base (pKaH = 4.6) and nucleophile, although it is a weaker base and poorer nucleophile than structurally similar aliphatic amines. ", http://www.nuclear-weapons.info/cde.htm#Corporal, CDC - NIOSH Pocket Guide to Chemical Hazrds, https://en.wikipedia.org/w/index.php?title=Aniline&oldid=989741451, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple CAS registry numbers, Chemical articles with multiple PubChem CIDs, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles with unsourced statements from May 2010, Wikipedia articles incorporating a citation from the 1911 Encyclopaedia Britannica with Wikisource reference, Wikipedia articles incorporating text from the 1911 Encyclopædia Britannica, Inconsistent wikidata for Commons category, Wikipedia articles incorporating a citation from EB9, Creative Commons Attribution-ShareAlike License, J. Fritzsche (1840) "Ueber das Anilin, ein neues Zersetzungsproduct des Indigo,", This page was last edited on 20 November 2020, at 19:36. 0000225214 00000 n 0000205574 00000 n 0000244989 00000 n

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